dr. 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 william 1:0,0,0,0;1:0,0,0,0 l 1:0,0,0,0 nyhan, 1:0,0,0,0 biochemist 1:0,0,0,0;2:0,0,0,0 at 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 the 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 university 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 of 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 california, 1:0,0,0,0 diego, 1:0,0,0,0 san 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 has 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 developed 1:0,0,0,0 major 1:0,0,0,0 advances 1:0,0,0,0 in 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 treatment 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 inherited 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 disorders. 1:0,0,0,0 f 1:0,0,0,0;2:0,0,0,0 o 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 r 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0 m 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 a 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 n 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 y 1:0,0,0,0;1:0,0,0,0 w 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 h 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 v 1:0,0,0,0 e 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 g 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0 tic 1:0,0,0,0 d 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 is 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 s 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0 , 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 . 1:0,0,0,0;1:0,0,0,0;3:0,0,0,0 th 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0 re 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 ly 1:0,0,0,0 u 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 ffe 1:0,0,0,0 rin 1:0,0,0,0 b 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0 t 1:0,0,0,0 c 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 ie 1:0,0,0,0 tific 1:0,0,0,0 leu 1:0,0,0,0 k 1:0,0,0,0;1:0,0,0,0;3:0,0,0,0 ro 1:0,0,0,0;3:0,0,0,0 when 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 it 1:0,0,0,0;3:0,0,0,0;3:0,0,0,0 takes 1:0,0,0,0 aniracle 1:0,0,0,0 ila 1:0,0,0,0 ll 1:0,0,0,0 joseph 1:0,0,0,0 family 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 northern 1:0,0,0,0 california 1:0,0,0,0;1:0,0,0,0 chemist, 1:0,0,0,0 chaimian 1:0,0,0,0 pediatrics 1:0,0,0,0;2:0,0,0,0 univer 1:0,0,0,0 endures 1:0,0,0,0 an 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 almost 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 unheard-of 1:0,0,0,0 tragedy. 1:0,0,0,0 over 1:0,0,0,0 sity 1:0,0,0,0 diego 1:0,0,0,0;2:0,0,0,0 (ucsd) 1:0,0,0,0 school 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 past 1:0,0,0,0 century, 1:0,0,0,0 more 1:0,0,0,0 than 1:0,0,0,0 100 1:0,0,0,0 members 1:0,0,0,0 11 1:0,0,0,0 medicine, 1:0,0,0,0 and 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 operator 1:0,0,0,0 one 1:0,0,0,0;1:0,0,0,0;3:0,0,0,0;3:0,0,0,0 world’s 1:0,0,0,0 generations 1:0,0,0,0 have 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 been 1:0,0,0,0 struck 1:0,0,0,0 down 1:0,0,0,0 by 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 fatal, 1:0,0,0,0 most 1:0,0,0,0 important 1:0,0,0,0 research 1:0,0,0,0;2:0,0,0,0 facili 1:0,0,0,0 disease 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 peculiar 1:0,0,0,0 to 1:0,0,0,0;1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 josephs. 1:0,0,0,0 ties 1:0,0,0,0 for 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 genetic 1:0,0,0,0;1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 di.sorders. 1:0,0,0,0 1975, 1:0,0,0,0 member 1:0,0,0,0 rosemary 1:0,0,0,0 silva 1:0,0,0,0 until 1:0,0,0,0;3:0,0,0,0;3:0,0,0,0 nyhan 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 roger 1:0,0,0,0 rosenberg— 1:0,0,0,0 wrote 1:0,0,0,0 desperate 1:0,0,0,0 letter 1:0,0,0,0 national 1:0,0,0,0;2:0,0,0,0 genet 1:0,0,0,0 chairman 1:0,0,0,0 department 1:0,0,0,0;2:0,0,0,0 neurology 1:0,0,0,0 ics 1:0,0,0,0 foundation 1:0,0,0,0 new 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 york 1:0,0,0,0;2:0,0,0,0 asking 1:0,0,0,0 help 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 texas 1:0,0,0,0 southwestern 1:0,0,0,0 medical 1:0,0,0,0;2:0,0,0,0 case 1:0,0,0,0;3:0,0,0,0;3:0,0,0,0 was 1:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 referred 1:0,0,0,0;2:0,0,0,0 l. 1:0,0,0,0 dallas—unraveled 1:0,0,0,0 josephs' 1:0,0,0,0 nyhan—world-renowned 1:0,0,0,0 sleuth, 1:0,0,0,0 bio 1:0,0,0,0 complex 1:0,0,0,0 genealogy, 1:0,0,0,0 no 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 un- 1:0,0,0,0 22 1:0,0,0,0 parade 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 • 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 april 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 26,1981 1:0,0,0,0;2:0,0,0,0;3:0,0,0,0 rd 2:0,0,0,0 r, 2:0,0,0,0 ltin 2:0,0,0,0 rta 2:0,0,0,0 fo 2:0,0,0,0 te 2:0,0,0,0;2:0,0,0,0 tre 2:0,0,0,0 checks 2:0,0,0,0 patient 2:0,0,0,0 ebtihal 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 aboaziza, 2:0,0,0,0;3:0,0,0,0 who 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 kept 2:0,0,0,0 alive 2:0,0,0,0 special 2:0,0,0,0;2:0,0,0,0 formula 2:0,0,0,0;3:0,0,0,0 fed 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 via 2:0,0,0,0 tube 2:0,0,0,0;3:0,0,0,0 into 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 baby's 2:0,0,0,0 nose. 2:0,0,0,0;3:0,0,0,0 afflicted 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0 infant 2:0,0,0,0;2:0,0,0,0 can 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 tolerate 2:0,0,0,0 still 2:0,0,0,0 develop 2:0,0,0,0 normally. 2:0,0,0,0 gotki 2:0,0,0,0 news 2:0,0,0,0 that, 2:0,0,0,0 properly 2:0,0,0,0 maintained, 2:0,0,0,0 children 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 like 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 expect 2:0,0,0,0 lead 2:0,0,0,0;2:0,0,0,0 nonnal 2:0,0,0,0 lives 2:0,0,0,0;2:0,0,0,0 without 2:0,0,0,0 impaired 2:0,0,0,0 brain 2:0,0,0,0 func 2:0,0,0,0 tion.” 2:0,0,0,0 victims 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 other 2:0,0,0,0;2:0,0,0,0 di.seases 2:0,0,0,0 are 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 not 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 always 2:0,0,0,0 as 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 fortu 2:0,0,0,0 nate. 2:0,0,0,0 researchers 2:0,0,0,0 made 2:0,0,0,0 progress 2:0,0,0,0 prolonging 2:0,0,0,0 with 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 lesch-nyhan 2:0,0,0,0;2:0,0,0,0 syndrome—an 2:0,0,0,0 illness 2:0,0,0,0 \ 2:0,0,0,0 discovered 2:0,0,0,0;3:0,0,0,0 along 2:0,0,0,0 michael 2:0,0,0,0 lesch, 2:0,0,0,0 chief 2:0,0,0,0 ] 2:0,0,0,0 cardiology 2:0,0,0,0 northwestern 2:0,0,0,0 / 2:0,0,0,0 illinois. 2:0,0,0,0 addition, 2:0,0,0,0 colleague, 2:0,0,0,0 bohdan 2:0,0,0,0 bakay, 2:0,0,0,0 ucsd, 2:0,0,0,0 pioneered 2:0,0,0,0 tests 2:0,0,0,0 * 2:0,0,0,0 identify 2:0,0,0,0 women 2:0,0,0,0 carriers 2:0,0,0,0 detect 2:0,0,0,0;3:0,0,0,0 syndrome 2:0,0,0,0;2:0,0,0,0 uterus. 2:0,0,0,0 but 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 there 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 yet 2:0,0,0,0;3:0,0,0,0 cure 2:0,0,0,0 nor 2:0,0,0,0 any 2:0,0,0,0;3:0,0,0,0 way 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 halt 2:0,0,0,0 its 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 appalling 2:0,0,0,0 symptoms. 2:0,0,0,0 families, 2:0,0,0,0 only 2:0,0,0,0;3:0,0,0,0 hope 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 counsel 2:0,0,0,0 ing. 2:0,0,0,0 once 2:0,0,0,0 female 2:0,0,0,0 earners 2:0,0,0,0 identified, 2:0,0,0,0 parents 2:0,0,0,0 know 2:0,0,0,0 their 2:0,0,0,0;3:0,0,0,0 baby 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 will 2:0,0,0,0 be 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 decide 2:0,0,0,0 whether 2:0,0,0,0 or 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 carry 2:0,0,0,0 pregnancy 2:0,0,0,0 term. 2:0,0,0,0 physicians 2:0,0,0,0 that 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 knowledge 2:0,0,0,0;3:0,0,0,0 gained 2:0,0,0,0 thmugh 2:0,0,0,0 sleuthing 2:0,0,0,0 may 2:0,0,0,0;2:0,0,0,0 eventually 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 shed 2:0,0,0,0 some 2:0,0,0,0 light 2:0,0,0,0 on 2:0,0,0,0;3:0,0,0,0 sudden 2:0,0,0,0 death 2:0,0,0,0;3:0,0,0,0 (crib 2:0,0,0,0 death). 2:0,0,0,0 “ 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 we 2:0,0,0,0 suspect 2:0,0,0,0;3:0,0,0,0 lot 2:0,0,0,0 inexplicable 2:0,0,0,0 deaths 2:0,0,0,0 young 2:0,0,0,0;2:0,0,0,0 due 2:0,0,0,0 inborn 2:0,0,0,0 metabolic 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 errors 2:0,0,0,0 could 2:0,0,0,0;3:0,0,0,0 detected 2:0,0,0,0 fetuses,” 2:0,0,0,0 says 2:0,0,0,0;2:0,0,0,0 lawrence 2:0,0,0,0 sweetman, 2:0,0,0,0 associate 2:0,0,0,0 professor 2:0,0,0,0 ucsd. 2:0,0,0,0 few 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 hospitals 2:0,0,0,0 country 2:0,0,0,0 equipped 2:0,0,0,0 staffs 2:0,0,0,0 trained 2:0,0,0,0 sophisticated 2:0,0,0,0 detection 2:0,0,0,0 management 2:0,0,0,0;3:0,0,0,0 abnormalities. 2:0,0,0,0 why 2:0,0,0,0 families 2:0,0,0,0 flckk 2:0,0,0,0 diego. 2:0,0,0,0 this 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 way,” 2:0,0,0,0 herman 2:0,0,0,0 vfeiner, 2:0,0,0,0 uprcxrted 2:0,0,0,0 his 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 from 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 three 2:0,0,0,0 years 2:0,0,0,0;2:0,0,0,0 ago, 2:0,0,0,0 if 2:0,0,0,0;3:0,0,0,0 anything 2:0,0,0,0 comes 2:0,0,0,0 up, 2:0,0,0,0 wetl 2:0,0,0,0 right 2:0,0,0,0 here.” 2:0,0,0,0 ann 2:0,0,0,0;2:0,0,0,0 gore 2:0,0,0,0 jersey 2:0,0,0,0 had 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 .same 2:0,0,0,0 idea. 2:0,0,0,0 1%8, 2:0,0,0,0 her 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 daughter 2:0,0,0,0 loren 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0 close 2:0,0,0,0 death. 2:0,0,0,0 despite 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 frequent 2:0,0,0,0 hospitalization 2:0,0,0,0 vomiting, 2:0,0,0,0 acid 2:0,0,0,0 urine, 2:0,0,0,0 respiratory 2:0,0,0,0 infections 2:0,0,0,0 seizures, 2:0,0,0,0 loren’s 2:0,0,0,0 condition 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 went 2:0,0,0,0;3:0,0,0,0 undiagnosed 2:0,0,0,0 until, 2:0,0,0,0 14 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0 months, 2:0,0,0,0;2:0,0,0,0 she 2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;2:0,0,0,0;3:0,0,0,0 nyhan. 2:0,0,0,0;3:0,0,0,0 then, 2:0,0,0,0 physical 2:0,0,0,0 intellectual 2:0,0,0,0 development 2:0,0,0,0 were 2:0,0,0,0 completely 2:0,0,0,0 arrested. 2:0,0,0,0 looked 2:0,0,0,0 acted 2:0,0,0,0 3-month-old 2:0,0,0,0 infant,” 2:0,0,0,0 recalls. 2:0,0,0,0 within 2:0,0,0,0;3:0,0,0,0 he 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 stabilized 2:0,0,0,0 pinpointed 2:0,0,0,0 cause 2:0,0,0,0;3:0,0,0,0 —a 2:0,0,0,0 disorder 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 called 2:0,0,0,0;3:0,0,0,0 methylalonic 2:0,0,0,0 acidemia. 2:0,0,0,0 now 2:0,0,0,0 old. 2:0,0,0,0;3:0,0,0,0 first 2:0,0,0,0;2:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 months 2:0,0,0,0;3:0,0,0,0;3:0,0,0,0 life, 2:0,0,0,0 hospitalized 2:0,0,0,0 continuously. 2:0,0,0,0 last 2:0,0,0,0 five 2:0,0,0,0 years, 2:0,0,0,0 admitted 2:0,0,0,0 all. 2:0,0,0,0 incredible 2:0,0,0,0 year 2:0,0,0,0 during 2:0,0,0,0 which 2:0,0,0,0 all 2:0,0,0,0;3:0,0,0,0 maturation 2:0,0,0,0 came 2:0,0,0,0 standstill, 2:0,0,0,0 thanks 2:0,0,0,0;3:0,0,0,0 sleuth 2:0,0,0,0 survived 2:0,0,0,0 overcome 2:0,0,0,0 many 2:0,0,0,0;3:0,0,0,0 handicaps 2:0,0,0,0 nearly 2:0,0,0,0 normal 2:0,0,0,0 life. 2:0,0,0,0 though 2:0,0,0,0 receives 2:0,0,0,0 academic 2:0,0,0,0 subjects, 2:0,0,0,0 mainstreamed 2:0,0,0,0 activities. 2:0,0,0,0 lrrren 2:0,0,0,0 extremely 2:0,0,0,0;3:0,0,0,0 critical 2:0,0,0,0 got 2:0,0,0,0 her,” 2:0,0,0,0 reports 2:0,0,0,0 grateful 2:0,0,0,0 gore. 2:0,0,0,0 gave 2:0,0,0,0 back 2:0,0,0,0 life 2:0,0,0,0 chance 2:0,0,0,0 talented, 2:0,0,0,0 well-adjusted 2:0,0,0,0 happy 2:0,0,0,0 person 2:0,0,0,0 is.” 2:0,0,0,0 locate 2:0,0,0,0 genetic-disease 2:0,0,0,0 center 2:0,0,0,0 your 2:0,0,0,0 area, 2:0,0,0,0 p, 2:0,0,0,0 write 2:0,0,0,0 call: 2:0,0,0,0 genetics 2:0,0,0,0 foundation, 2:0,0,0,0 dept. 2:0,0,0,0 555 2:0,0,0,0 ) 2:0,0,0,0 w. 2:0,0,0,0 57th 2:0,0,0,0 st., 2:0,0,0,0 room 2:0,0,0,0 1240\ 2:0,0,0,0 york, 2:0,0,0,0 n. 2:0,0,0,0 y. 2:0,0,0,0 looisl 2:0,0,0,0 (212 2:0,0,0,0 586-5800. 2:0,0,0,0 25 2:0,0,0,0 similar 3:0,0,0,0 defects 3:0,0,0,0 —including 3:0,0,0,0 '-jjionic 3:0,0,0,0 acidem 3:0,0,0,0 ia-the 3:0,0,0,0 ever 3:0,0,0,0 derstood 3:0,0,0,0 pattern 3:0,0,0,0 likely. 3:0,0,0,0 aboaziza. 3:0,0,0,0 diagnosed------ 3:0,0,0,0 blight 3:0,0,0,0 devastating 3:0,0,0,0 them. 3:0,0,0,0 after 3:0,0,0,0;3:0,0,0,0 feeding 3:0,0,0,0 these 3:0,0,0,0 types 3:0,0,0,0 cannot 3:0,0,0,0 me 3:0,0,0,0 controlled 3:0,0,0,0 through 3:0,0,0,0;3:0,0,0,0 work, 3:0,0,0,0 investigators 3:0,0,0,0 deter 3:0,0,0,0 disorders 3:0,0,0,0 tricky,” 3:0,0,0,0 observes. 3:0,0,0,0 meticulously 3:0,0,0,0 monitored 3:0,0,0,0 diet 3:0,0,0,0 therapy. 3:0,0,0,0 tabolize 3:0,0,0,0 food 3:0,0,0,0;3:0,0,0,0 properly. 3:0,0,0,0 them, 3:0,0,0,0 eating 3:0,0,0,0 mined 3:0,0,0,0 hereditary. 3:0,0,0,0 doesn’t 3:0,0,0,0 certain 3:0,0,0,0;3:0,0,0,0 amount 3:0,0,0,0;3:0,0,0,0 foods 3:0,0,0,0 containing 3:0,0,0,0 amino 3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 acids 3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 unfortunately, 3:0,0,0,0 de 3:0,0,0,0;3:0,0,0,0 prognosis, 3:0,0,0,0 however, 3:0,0,0,0;3:0,0,0,0 harsh. 3:0,0,0,0 protein, 3:0,0,0,0 can’t 3:0,0,0,0 survive. 3:0,0,0,0 catch 3:0,0,0,0 veloped 3:0,0,0,0 too 3:0,0,0,0 late 3:0,0,0,0 eric, 3:0,0,0,0;3:0,0,0,0 produces 3:0,0,0,0 toxic 3:0,0,0,0 reaction. 3:0,0,0,0;3:0,0,0,0 untreated, 3:0,0,0,0 determining 3:0,0,0,0 exact 3:0,0,0,0 minimal 3:0,0,0,0 baby’s 3:0,0,0,0 become 3:0,0,0,0;3:0,0,0,0 prototype 3:0,0,0,0 fetuses 3:0,0,0,0 diagnose 3:0,0,0,0 they 3:0,0,0,0 dehydrated, 3:0,0,0,0 severely 3:0,0,0,0 successful 3:0,0,0,0 host 3:0,0,0,0 tarded 3:0,0,0,0 comatose. 3:0,0,0,0 before 3:0,0,0,0 symptoms 3:0,0,0,0;3:0,0,0,0 appear 3:0,0,0,0 (which 3:0,0,0,0 oc 3:0,0,0,0 tin 3:0,0,0,0 cur 3:0,0,0,0 time 3:0,0,0,0;3:0,0,0,0 between 3:0,0,0,0 ages 3:0,0,0,0 16 3:0,0,0,0 45, 3:0,0,0,0 already 3:0,0,0,0;3:0,0,0,0 children). 3:0,0,0,0 treatment. 3:0,0,0,0 elim 3:0,0,0,0 inate 3:0,0,0,0 offspring 3:0,0,0,0 affected 3:0,0,0,0 parent 3:0,0,0,0 remain 3:0,0,0,0 childless. 3:0,0,0,0 such 3:0,0,0,0 diseases 3:0,0,0,0 do 3:0,0,0,0 yield 3:0,0,0,0 se 3:0,0,0,0 crets 3:0,0,0,0 easily. 3:0,0,0,0 fortunately, 3:0,0,0,0 type 3:0,0,0,0 pecu 3:0,0,0,0 liar 3:0,0,0,0 single 3:0,0,0,0 unusual. 3:0,0,0,0 genetically 3:0,0,0,0 transmitted 3:0,0,0,0 dis 3:0,0,0,0;3:0,0,0,0 orders 3:0,0,0,0 general 3:0,0,0,0 not: 3:0,0,0,0 scientists 3:0,0,0,0 identified 3:0,0,0,0 30,000—^‘approxi 3:0,0,0,0 mately 3:0,0,0,0 1300 3:0,0,0,0 syndromes 3:0,0,0,0 since 3:0,0,0,0;3:0,0,0,0 1966,” 3:0,0,0,0 according 3:0,0,0,0 rosenberg. 3:0,0,0,0 nyhan’s 3:0,0,0,0 patients 3:0,0,0,0 include 3:0,0,0,0 boy 3:0,0,0,0 17 3:0,0,0,0 looks 3:0,0,0,0 underdeveloped 3:0,0,0,0 11- 3:0,0,0,0 year-old. 3:0,0,0,0 sits 3:0,0,0,0 propped 3:0,0,0,0 up 3:0,0,0,0;3:0,0,0,0 wheel 3:0,0,0,0 chair, 3:0,0,0,0 hands 3:0,0,0,0 buried 3:0,0,0,0 under 3:0,0,0,0 mounds 3:0,0,0,0 pillows 3:0,0,0,0 protect 3:0,0,0,0 him 3:0,0,0,0 compul 3:0,0,0,0 sion 3:0,0,0,0 mutilate 3:0,0,0,0 himself. 3:0,0,0,0 speech 3:0,0,0,0 garbled, 3:0,0,0,0 periodically 3:0,0,0,0 screams 3:0,0,0,0 obscenities. 3:0,0,0,0 victim 3:0,0,0,0;3:0,0,0,0 lesch- 3:0,0,0,0 syndrome, 3:0,0,0,0 caused 3:0,0,0,0 inher 3:0,0,0,0 ited, 3:0,0,0,0 defective 3:0,0,0,0 enzyme. 3:0,0,0,0;3:0,0,0,0 known 3:0,0,0,0 cure. 3:0,0,0,0 diego’s 3:0,0,0,0 hospital,' 3:0,0,0,0 9 3:0,0,0,0 old, 3:0,0,0,0 customized, 3:0,0,0,0 artificial 3:0,0,0,0 inserted 3:0,0,0,0 lived 3:0,0,0,0 hospital 3:0,0,0,0;3:0,0,0,0 ward 3:0,0,0,0 birth 3:0,0,0,0 expected 3:0,0,0,0 return 3:0,0,0,0 home 3:0,0,0,0 birthday. 3:0,0,0,0 she, 3:0,0,0,0 too, 3:0,0,0,0 malfunctioning 3:0,0,0,0 affects 3:0,0,0,0 body’s 3:0,0,0,0 ability 3:0,0,0,0 convert 3:0,0,0,0 protein 3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 energy. 3:0,0,0,0 ease, 3:0,0,0,0 p 3:0,0,0,0;3:0,0,0,0 io 3:0,0,0,0 ic 3:0,0,0,0 id 3:0,0,0,0 ia 3:0,0,0,0 ille 3:0,0,0,0 boazizas’ 3:0,0,0,0 child 3:0,0,0,0 1974 3:0,0,0,0 en 3:0,0,0,0 6 3:0,0,0,0 weeks 3:0,0,0,0 ebtihal—a 3:0,0,0,0 treatment, 3:0,0,0,0 work 3:0,0,0,0 nvhap's 3:0,0,0,0 role 3:0,0,0,0 unraveling 3:0,0,0,0 conundrums 3:0,0,0,0 began 3:0,0,0,0 1960 3:0,0,0,0 babv 3:0,0,0,0 named 3:0,0,0,0 eric 3:0,0,0,0;3:0,0,0,0;3:0,0,0,0;3:0,0,0,0 johns 3:0,0,0,0;3:0,0,0,0 hopkins 3:0,0,0,0 i 3:0,0,0,0 medicine. 3:0,0,0,0 unusual 3:0,0,0,0 case. 3:0,0,0,0 undergone 3:0,0,0,0 surgery 3:0,0,0,0;3:0,0,0,0 another 3:0,0,0,0 pyloric 3:0,0,0,0 stenosis, 3:0,0,0,0 resulting 3:0,0,0,0 narrowing 3:0,0,0,0 digestive 3:0,0,0,0 tract. 3:0,0,0,0 unless 3:0,0,0,0 corrected 3:0,0,0,0 sur 3:0,0,0,0 gically, 3:0,0,0,0 brings 3:0,0,0,0 digestion 3:0,0,0,0 halt, 3:0,0,0,0 backing 3:0,0,0,0 causing 3:0,0,0,0 severe 3:0,0,0,0 vomiting. 3:0,0,0,0 operation, 3:0,0,0,0 persisted 3:0,0,0,0 infant, 3:0,0,0,0 weakened 3:0,0,0,0 vomiting 3:0,0,0,0 hydration, 3:0,0,0,0 lapsed 3:0,0,0,0 coma. 3:0,0,0,0 condition. 3:0,0,0,0 arrived 3:0,0,0,0 hop 3:0,0,0,0 kins. 3:0,0,0,0 nvhan—at 3:0,0,0,0 35-year-6ld 3:0,0,0,0 associate^rofessor 3:0,0,0,0 pediatrics—was 3:0,0,0,0 consult. 3:0,0,0,0 fact 3:0,0,0,0 hadn’t 3:0,0,0,0 cor 3:0,0,0,0 rected 3:0,0,0,0 eric’s 3:0,0,0,0;3:0,0,0,0 told 3:0,0,0,0 us 3:0,0,0,0;3:0,0,0,0 probably 3:0,0,0,0 didn’t 3:0,0,0,0 fit 3:0,0,0,0 our 3:0,0,0,0 established 3:0,0,0,0 diseases,” 3:0,0,0,0 explains. 3:0,0,0,0 “an 3:0,0,0,0 analysis 3:0,0,0,0 blood 3:0,0,0,0 urine 3:0,0,0,0 revealed 3:0,0,0,0 elevated 3:0,0,0,0 level 3:0,0,0,0 glycine, 3:0,0,0,0 bl(x)d, 3:0,0,0,0 leading 3:0,0,0,0 veiy 3:0,0,0,0 possibly 3:0,0,0,0 intolerance 3:0,0,0,0 pro 3:0,0,0,0 tein.” 3:0,0,0,0 complex. 3:0,0,0,0 ques 3:0,0,0,0 tion 3:0,0,0,0 was: 3:0,0,0,0 what 3:0,0,0,0 part 3:0,0,0,0 protein? 3:0,0,0,0 sleuthing. 3:0,0,0,0 isolated 3:0,0,0,0 each 3:0,0,0,0 comprise 3:0,0,0,0 and, 3:0,0,0,0 one, 3:0,0,0,0 them 3:0,0,0,0 mapping 3:0,0,0,0 infant’s 3:0,0,0,0 biochemical 3:0,0,0,0 weeks, 3:0,0,0,0 answer. 3:0,0,0,0 suffering 3:0,0,0,0 pro- 3:0,0,0,0 23 3:0,0,0,0